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Life Science Research and Sustainable Development ISBN: 978-98-84663-33-9

In vertebrates and invertebrates, cypermethrin acts mainly on the nervous system. Cypermethrin
is both a stomach poison and a contact insecticide (Jin and Webster, 1998). In the peripheral
nervous system of the frog, its primary action is to induce noticeably repetitive activity and
produce trains of nerve impulses as a result of altering ion permeability of nerve membranes
(Vijverberg and van den Bercken, 1990; and Siegfried, 1993). These long-lasting trains can cause
hundreds to thousands of repetitive nerve impulses in the sense organs. This repetitive activity
is induced by pyrethroid damage to the voltage-dependent sodium channel, causing sodium
channels to stay open much longer than normal. (Vijverberg and van den Bercken, 1990).
Cypermethrin has been shown to inhibit ATPase enzymes involved in movement of ions
against a concentration gradient which are regulated by active transport. This action is especially
critical to fish and aquatic insects where ATPase enzymes provide the energy necessary to active
transport, and very important at sites of oxygen exchange. ATPase inhibition and disruption of
active transport, possibly affect ion movement and the ability to maintain ion balance, and disrupt

https://jesjalna.org/Zoology-Publications/index.html 98 Department of Zoology, J. E. S. College, Jalna